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Purpose: This study evaluated biological rhythm disorders in patients with myofascial pain syndrome (MPS).
Subjects and Methods: We included 82 patients with MPS and 94 controls for the study. Biological rhythm disturbances
(i.e. sleep, activity, social, and eating patterns) were evaluated by the Biological Rhythms Interview of Assessment in
Neuropsychiatry (BRIAN). Pain intensity was evaluated by visual analogue scale (VAS). The psychological conditions of
the patients were evaluated by the Beck Depression Inventory (BDI).
Results: The baseline characteristics were similar between the two groups (p > 0.05). The BDI, and BRAIN total, sleep,
activity, social, and eating subscores were higher in patients with MPS than in the controls (all p < 0.001). In addition,
a significant correlation was found between BDI and BRIAN total, sleep, activity subscores (all p < 0.001). No significant
correlation was detected between BDI and BRIAN social, eating subscores. There were no significant correlations
between the VAS, BRIAN, and BDI scores in patients with MPS, as well.
Conclusion: Biological rhythm disturbances in MPS seem to be marked and there is an important relationship between
rhythm disorders and MPS. The physician should keep in mind these disturbances for the efficient treatment.
Keywords: Myofascial syndrome, depression, biological rhythms.


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